Madan is interested in data science approaches to make biological discoveries and reveal fundamental principles of biological systems. He employs and develops computational and experimental methods to study biological systems at different scales of complexity: from systems at the atomic level (e.g., structures), to the network of interactions between molecules (e.g., protein interaction networks), to the level of an entire population (e.g., variation in the human population and cancer genomes). He envisions that his group’s research findings will help us better understand how mutations cause cancer and other diseases. This knowledge can be used in biotechnology, drug discovery, and personalized medicine.
Before joining St. Jude, Madan was a Programme Leader at the MRC Laboratory of Molecular Biology in Cambridge, UK. His group joined the Center for Data Driven Discovery, and the Structural Biology Department at St. Jude in July 2020. Please see Research and About Madan for more details.