Regulatory Genomics and Systems Biology

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Collaborative research with Sarah Teichmann’s group published in Molecular Cell

Through a systematic effort that integrated multiple genome-scale datasets describing various aspects of DNA binding proteins, we show that activators tend to have binding site similarity to nucleosomal histones, resulting in competition for binding to DNA, while repressors show the opposite trend. You can read the paper here and the LMB press release here.

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