Regulatory Genomics and Systems Biology

Our perspective on the hidden codes that constrain protein evolution is published in Science

In this essay, we discuss how regulatory elements within protein-coding regions (such as transcription factor binding) can influence codon choice and amino acid preference that are independent of protein structure or function. We discuss how there may be conflicts between codes and highlight that the redundancy in the genetic code might facilitate the existence of multiple overlapping regulatory codes within protein-coding regions of the genome. You can read the Perspective here.



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